The Pharmaceutical Organic Chemistry research group (PhOC) is an emerging group set up when School of Pharmacy of Albacete was founded in 2010. Our research interest focus on three main objectives:
- Aggregation-induced emission. By appropriately modifying the chemical structure of the compounds it is possible to modulate their fluorescent properties in solution but also in the solid state or when aggregated. And this fluorescence can be greater than in solution, giving rise to the AIE phenomenon. Aggregates with AIE are fluorescent and have a potential use in various applications such as sensors, drug-delivery and biological signalling.
- Biocompatible fluorescence sensors. Multivalent conjugated non-toxic and water soluble macromolecules as platforms for the incorporation of bioactives structures. These systems change their fluorescence properties in the presence of microstimulus produced by a pathological process.
- Amphiphilic pseudendrimers for Drug Delivery. The self-assembling of amphiphilic molecules leads to micelles that hold hydrophobic drugs. Their release may be control by the appropriate decoration of the hydrophilic part by disaggregation by external microstimulus. The delivery of the desired drug can be monitored by the fluorescence properties of the amphiphilic molecules that provides a different response upon aggregation o disaggregation.
- New antibacterial drugs. A series of polyanionic and polycationic antibacterial compounds on the periphery of conjugated rigid core has been developed. The higly control on the synthesis and the structure allow us to establish a structure-activity relationship.
- Machine learning in organic synthesis. Data mining strategies apply in synthesis of organic chemistry. The use of machine-learning algorithms and statistics to extract, predict and/or decide the optimum reaction conditions for their application in the organic synthesis laboratory.
The most recent information about these projects can be found in the group’s publications, but a brief introduction to each is provided below.
NEWS: The deadline for application for the scholarships for Postdoctoral stay at the UCLM is now open. If you are interested in doing your thesis in our research group, please contact us: JoaquinC.Garcia@uclm.es
The PhOC research group recently joint: DENDRIMERS NETWORK FOR BIOMEDICAL APPLICATIONS (DENDROBIONET)